Spravato® (Esketamine) Treatment for Depression in The Woodlands, TX

A New Option for Treatment-Resistant Depression

At The Woodlands Wellness & Mind Spa, we understand how difficult it can be to find relief when traditional antidepressant treatments haven’t worked. That’s why we’re proud to offer Spravato® (esketamine) — an innovative, FDA-approved nasal spray for adults living with treatment-resistant depression (TRD) or depressive symptoms in major depressive disorder (MDD) with suicidal thoughts or actions.

Spravato® works differently from traditional antidepressants by targeting the NMDA receptor, helping restore connections in brain regions involved in mood and emotional regulation. Many patients begin noticing improvement within hours to days of treatment.

What is Spravato® (Esketamine)?

Spravato® (esketamine) is an FDA-approved nasal spray designed for adults with treatment-resistant depression (TRD) or major depressive disorder (MDD) with suicidal thoughts or actions.

Unlike traditional antidepressants that target serotonin, Spravato® works on the glutamate system—a pathway linked to neuroplasticity, or the brain’s ability to form new connections.

By activating NMDA receptors, Spravato® can help “reset” communication patterns in brain regions involved in mood, motivation, and emotional regulation. Many patients describe results as feeling like a “lift,” “lightness,” or the ability to function again.

Who Qualifies for Spravato®?

You may be a candidate for Spravato® if:

You’ve tried at least two antidepressants at therapeutic doses without adequate relief
You have treatment-resistant depression
You are experiencing depressive symptoms with suicidal thoughts or behaviors
You are currently on an oral antidepressant (Spravato® is taken with an antidepressant)
You are seeking a treatment that works differently from standard medications

Spravato® is not typically appropriate for individuals with certain uncontrolled medical conditions, a history of aneurysm, or severe substance misuse.

During your consultation, our physician will perform a thorough evaluation to determine if this treatment is right for you.

How Spravato® Treatment Works

Spravato® is a self-administered nasal spray taken under medical supervision. After dosing, the medication is absorbed through the nasal passages and begins acting on NMDA receptors in the brain. This process enhances neuroplasticity and may help restore disrupted mood circuits.

Spravato® is always administered in-clinic, never at home, to ensure comfort, monitoring, and safety.

Typical clinical schedule:

Weeks 1–4: Twice weekly
Weeks 5–8: Once weekly
Week 9 and beyond: Every 1–2 weeks for maintenance, depending on your response

Your provider will personalize your schedule based on your symptoms and progress.

What to Expect During Treatment?

Your Spravato® journey is guided with compassion and clinical expertise.

Each session is administered in our relaxing and private treatment rooms.
You’ll self-administer Spravato® nasal spray under the supervision of our licensed clinical team.
You’ll rest comfortably for about 2 hours after dosing while we monitor your progress and well-being.
Most patients begin with two treatments per week, transitioning to once weekly or every other week as symptoms improve.

Our goal is to ensure you feel safe, supported, and cared for throughout every step of your healing process

Side Effects & Safety

Spravato® is FDA-approved and has been studied extensively.
Common side effects are usually mild and temporary, occurring during or shortly after treatment:

Dissociation (feeling “detached” or dreamy)
Dizziness or lightheadedness
Temporary blood pressure increase
Nausea
Feeling tired or “floating”
Mild anxiety during onset
Headache

These effects typically resolve within the 2-hour observation period.
Our medical team monitors you throughout every session to ensure comfort and safety.

Spravato® has no at-home use, reducing risks of misuse and ensuring proper medical supervision at all times.

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Expected Timelines for Improvement

One of the unique benefits of Spravato® is how quickly some patients begin to feel relief.

Within hours: Some patients notice a shift in mood, clarity, or decreased mental heaviness
Within several days: Many experience reduced depressive symptoms
By 2–4 weeks: Research shows significant improvement in individuals with treatment-resistant depression
Long-term: Maintenance sessions can help sustain progress
Response rates: Clinical studies show about 45–50% of patients respond, even when multiple antidepressants have failed

Our team will track your progress closely and adjust your care plan to help you get the greatest benefit.

Insurance Coverage

We’re committed to making treatment accessible and affordable.

We are in-network with:

Cigna (for Spravato® treatment)

Why Choose The Woodlands Wellness & Mind Spa

Personalized, evidence-based care plans
Calm, supportive environment
Compassionate clinicians focused on your well-being
Holistic approach integrating wellness, therapy, and medical support

We continue to pursue additional insurance partnerships and will update this page as new networks become available.

If you or someone you love is struggling with depression that hasn’t improved with other treatments, Spravato® may be the next step toward relief and healing.